The Great Effect of Cheap Elements: Lithium Supplements Reverse Memory in Mice

A study published in the journal Nature suggests that supplementing lithium in the brain may prevent or even reverse Alzheimer's disease. The study found through analysis of human brain tissue and mouse experiments that the decrease in brain lithium concentration is closely related to memory loss and pathological features of Alzheimer's disease, such as beta amyloid plaques and tau protein tangles. Experiments have shown that specific types of lithium supplements, such as lithium orotate, can reverse brain lesions and restore memory in mice, while commonly used lithium carbonate has no such effect.

Neuroscientists evaluate that this discovery is groundbreaking because existing drugs only target a single pathological target, while lithium may cover multiple mechanisms of Alzheimer's disease. There are over 55 million dementia patients worldwide, most of whom have Alzheimer's disease. Existing therapies can only delay cognitive decline and cannot prevent or restore function.

Lithium has been used as an emotion regulator in history and became the standard therapy for treating bipolar disorder in the 1970s. Epidemiological studies found that the incidence rate of dementia was low in areas with trace lithium in drinking water, but the results of previous clinical trials were inconsistent. The research team from Harvard Medical School has confirmed for the first time that lithium naturally exists in the brain and revealed its mechanism of action in Alzheimer's disease: β - amyloid plaques "capture" lithium, leading to insufficient lithium in the brain; Lithium deficiency leads to the formation of more plaques, thus forming a vicious cycle. Lithium orotate has shown significant therapeutic effects in experiments due to its resistance to plaque binding.

Although the results of the mouse experiment need further verification, researchers remain cautiously optimistic. Future research needs to clarify the initiation mechanism of lithium loss and advance clinical trials. If proven effective, lithium is expected to become a breakthrough choice for the treatment of Alzheimer's disease.

Science Newsletter website (www.sciencenews. org)

New hope for space agriculture? Scientists discover key gene for plant 'gravity resistance'

Moss, although structurally simple, can grow in the most extreme environments on Earth, such as Antarctica, deserts, and mountains. A research team from Hokkaido University in Japan found through experiments that moss not only does not show inhibition in a hypergravity environment, but also exhibits stronger growth ability.

In the experiment, researchers cultured Physcomitrium patens in artificially simulated environments of 3, 6, and 10 times the Earth's gravity for eight weeks. The results showed that the photosynthetic efficiency of moss increased by 36% to 52% under 6 and 10 times gravity, while the chloroplast volume increased and the CO ₂ diffusion ability was enhanced. This discovery, published in the journal Science Advances, is in stark contrast to previous research - for example, a study by Savitri Baipurna University in India found that photosynthesis in wheat sharply decreases under 500 times gravity.

The research team also discovered a key gene named "IBSH1". Activating this gene under normal gravity can simulate the effect of supergravity, causing chloroplast enlargement and a maximum increase in photosynthetic efficiency of 70%. This discovery suggests that plants may have innate potential to adapt to different gravitational environments, and even provides clues for understanding the evolution of ancient mosses from aquatic to terrestrial. In the future, this gene may help improve crops and enhance agricultural productivity.

This study not only reveals the amazing adaptability of moss, but also provides new research directions for future space agriculture and crop improvement.

Daily Science website (www.Sciencedaily. com)

New anti-cancer strategy: prevent tumors from "eating", significantly improve treatment effectiveness

Scientists have discovered that preventing tumors from stealing nutrients can alter their surrounding microenvironment, making them more vulnerable to attacks from the immune system and treatment methods. In mouse experiments, this strategy significantly improved the efficacy of chemotherapy and immunotherapy for pancreatic cancer.

Cancer cells do not grow in isolation, but rather obtain nutrients by interacting with the tumor microenvironment, including immune cells, connective tissue, and blood vessels. For example, pancreatic ductal adenocarcinoma (PDAC) can plunder resources from the extracellular matrix through "macrophagy", leading to microenvironmental fibrosis and hindering the penetration of immune cells and drugs.

The research team from the Sanford Burnham Prebes Institute of Medicine (SBP) in the United States published a study in the journal Cancer Cell, confirming that blocking the action of macrophagin can reshape the tumor microenvironment: reduce collagen deposition, soften tissue, and promote T cell infiltration and blood vessel dilation. This change makes immunotherapy and chemotherapy more effective.

The research focuses on "cancer associated fibroblasts" (CAFs). These cells are often hijacked by tumors to provide growth support. After blocking the action of macrocytosis, CAFs undergo subtype transformation due to glutamine deficiency, transitioning from pro fibrotic myofibroblasts to pro-inflammatory CAFs, thereby improving the microenvironment.

In the experiment, the combined use of the giant cell inhibitor EIPA and anti-PD-1 antibody significantly inhibited tumor metastasis and prolonged survival in mice. Similarly, after pre-treatment with EIPA, combined with chemotherapy drug gemcitabine, not only synergistically inhibits tumor growth but also reduces pulmonary micrometastasis.

Researchers believe that blocking tumor energy plunder is a potential strategy to improve the therapeutic effect, especially for high mortality cancers such as pancreatic cancer. In the future, we will further explore how to develop more efficient combination therapies by regulating the microenvironment.

Saite Technology Daily website（ https://scitechdaily.com ）

Does the multiverse really exist? New quantum technologies may provide answers

The research team at the University of Colorado Denver has made significant breakthroughs in the field of quantum technology, which may provide new tools for verifying science fiction theories such as the multiverse, while driving changes in fields such as medicine and physics. The relevant research was published on the cover of the journal Advanced Quantum Technologies.

Traditionally, generating super strong electromagnetic fields relies on giant facilities such as the Large Hadron Collider, which are not only costly but also extremely complex to operate. The team has innovatively developed a silicon-based chip level material that can generate ultra strong electromagnetic fields in laboratory environments that were previously unattainable. This material reduces high-energy field observation equipment to the size of a thumb by controlling the energy and heat generated by electronic oscillations, laying the foundation for future miniaturized particle accelerators.

This technology was designed by the University of Colorado Denver and tested at the SLAC National Accelerator Laboratory under the US Department of Energy. At present, the school has applied for temporary patents in the United States and internationally.

At the application level, this breakthrough may give rise to gamma ray laser technology, enabling precise medical treatment at the atomic nucleus level, such as precise removal of cancer cells without damaging healthy tissues. At the same time, extreme plasma technology can also be used to verify the theory of the nature of the universe, including cutting-edge propositions such as the multiverse hypothesis. Researchers say that although practical applications still require years of exploration, this technology has the potential to become another major innovation that will change the world after lasers and chips.

The team will return to the SLAC laboratory to optimize the technical solution in the next step. It is worth noting that the cycle of such disruptive research often lasts for decades, and its basic work can be traced back to the research on antimatter accelerators in 2018. But scientists believe that this technology is likely to achieve a leap from theory to application within this century.

The Great Effect of Cheap Elements: Lithium Supplements Reverse Memory in Mice

A study published in the journal Nature suggests that supplementing lithium in the brain may prevent or even reverse Alzheimer's disease. The study found through analysis of human brain tissue and mouse experiments that the decrease in brain lithium concentration is closely related to memory loss and pathological features of Alzheimer's disease, such as beta amyloid plaques and tau protein tangles. Experiments have shown that specific types of lithium supplements, such as lithium orotate, can reverse brain lesions and restore memory in mice, while commonly used lithium carbonate has no such effect.

Neuroscientists evaluate that this discovery is groundbreaking because existing drugs only target a single pathological target, while lithium may cover multiple mechanisms of Alzheimer's disease. There are over 55 million dementia patients worldwide, most of whom have Alzheimer's disease. Existing therapies can only delay cognitive decline and cannot prevent or restore function.

Lithium has been used as an emotion regulator in history and became the standard therapy for treating bipolar disorder in the 1970s. Epidemiological studies found that the incidence rate of dementia was low in areas with trace lithium in drinking water, but the results of previous clinical trials were inconsistent. The research team from Harvard Medical School has confirmed for the first time that lithium naturally exists in the brain and revealed its mechanism of action in Alzheimer's disease: β - amyloid plaques "capture" lithium, leading to insufficient lithium in the brain; Lithium deficiency leads to the formation of more plaques, thus forming a vicious cycle. Lithium orotate has shown significant therapeutic effects in experiments due to its resistance to plaque binding.

Although the results of the mouse experiment need further verification, researchers remain cautiously optimistic. Future research needs to clarify the initiation mechanism of lithium loss and advance clinical trials. If proven effective, lithium is expected to become a breakthrough choice for the treatment of Alzheimer's disease.

Science Newsletter website (www.sciencenews. org)

New hope for space agriculture? Scientists discover key gene for plant 'gravity resistance'

Moss, although structurally simple, can grow in the most extreme environments on Earth, such as Antarctica, deserts, and mountains. A research team from Hokkaido University in Japan found through experiments that moss not only does not show inhibition in a hypergravity environment, but also exhibits stronger growth ability.

In the experiment, researchers cultured Physcomitrium patens in artificially simulated environments of 3, 6, and 10 times the Earth's gravity for eight weeks. The results showed that the photosynthetic efficiency of moss increased by 36% to 52% under 6 and 10 times gravity, while the chloroplast volume increased and the CO ₂ diffusion ability was enhanced. This discovery, published in the journal Science Advances, is in stark contrast to previous research - for example, a study by Savitri Baipurna University in India found that photosynthesis in wheat sharply decreases under 500 times gravity.

The research team also discovered a key gene named "IBSH1". Activating this gene under normal gravity can simulate the effect of supergravity, causing chloroplast enlargement and a maximum increase in photosynthetic efficiency of 70%. This discovery suggests that plants may have innate potential to adapt to different gravitational environments, and even provides clues for understanding the evolution of ancient mosses from aquatic to terrestrial. In the future, this gene may help improve crops and enhance agricultural productivity.

This study not only reveals the amazing adaptability of moss, but also provides new research directions for future space agriculture and crop improvement.

Daily Science website (www.Sciencedaily. com)

New anti-cancer strategy: prevent tumors from "eating", significantly improve treatment effectiveness

Scientists have discovered that preventing tumors from stealing nutrients can alter their surrounding microenvironment, making them more vulnerable to attacks from the immune system and treatment methods. In mouse experiments, this strategy significantly improved the efficacy of chemotherapy and immunotherapy for pancreatic cancer.

Cancer cells do not grow in isolation, but rather obtain nutrients by interacting with the tumor microenvironment, including immune cells, connective tissue, and blood vessels. For example, pancreatic ductal adenocarcinoma (PDAC) can plunder resources from the extracellular matrix through "macrophagy", leading to microenvironmental fibrosis and hindering the penetration of immune cells and drugs.

The research team from the Sanford Burnham Prebes Institute of Medicine (SBP) in the United States published a study in the journal Cancer Cell, confirming that blocking the action of macrophagin can reshape the tumor microenvironment: reduce collagen deposition, soften tissue, and promote T cell infiltration and blood vessel dilation. This change makes immunotherapy and chemotherapy more effective.

The research focuses on "cancer associated fibroblasts" (CAFs). These cells are often hijacked by tumors to provide growth support. After blocking the action of macrocytosis, CAFs undergo subtype transformation due to glutamine deficiency, transitioning from pro fibrotic myofibroblasts to pro-inflammatory CAFs, thereby improving the microenvironment.

In the experiment, the combined use of the giant cell inhibitor EIPA and anti-PD-1 antibody significantly inhibited tumor metastasis and prolonged survival in mice. Similarly, after pre-treatment with EIPA, combined with chemotherapy drug gemcitabine, not only synergistically inhibits tumor growth but also reduces pulmonary micrometastasis.

Researchers believe that blocking tumor energy plunder is a potential strategy to improve the therapeutic effect, especially for high mortality cancers such as pancreatic cancer. In the future, we will further explore how to develop more efficient combination therapies by regulating the microenvironment.

Saite Technology Daily website（ https://scitechdaily.com ）

Does the multiverse really exist? New quantum technologies may provide answers

The research team at the University of Colorado Denver has made significant breakthroughs in the field of quantum technology, which may provide new tools for verifying science fiction theories such as the multiverse, while driving changes in fields such as medicine and physics. The relevant research was published on the cover of the journal Advanced Quantum Technologies.

Traditionally, generating super strong electromagnetic fields relies on giant facilities such as the Large Hadron Collider, which are not only costly but also extremely complex to operate. The team has innovatively developed a silicon-based chip level material that can generate ultra strong electromagnetic fields in laboratory environments that were previously unattainable. This material reduces high-energy field observation equipment to the size of a thumb by controlling the energy and heat generated by electronic oscillations, laying the foundation for future miniaturized particle accelerators.

This technology was designed by the University of Colorado Denver and tested at the SLAC National Accelerator Laboratory under the US Department of Energy. At present, the school has applied for temporary patents in the United States and internationally.

At the application level, this breakthrough may give rise to gamma ray laser technology, enabling precise medical treatment at the atomic nucleus level, such as precise removal of cancer cells without damaging healthy tissues. At the same time, extreme plasma technology can also be used to verify the theory of the nature of the universe, including cutting-edge propositions such as the multiverse hypothesis. Researchers say that although practical applications still require years of exploration, this technology has the potential to become another major innovation that will change the world after lasers and chips.

The team will return to the SLAC laboratory to optimize the technical solution in the next step. It is worth noting that the cycle of such disruptive research often lasts for decades, and its basic work can be traced back to the research on antimatter accelerators in 2018. But scientists believe that this technology is likely to achieve a leap from theory to application within this century.